Injection of Lymphocytes From Haplo-identical Donor Following Chemotherapy in Patients With High-risk Acute Myeloblastic Leukemia Not Eligible for an Allogeneic Hematopoietic Stem Cell Transplantation

Inclusion Criteria: * age ≥18 years * patients with de novo or secondary AML, with an unfavorable or intermediate karyotype (according to the 2017 ELN classification), or patients with relapsing AML who may receive second-line treatment * not candidates for intensive induction, for the following reasons * 75 years or ≥ 18 to 74 years and at least one of the following comorbidities: PS ≥ 2 or a history of heart failure requiring treatment or LVEF ≤ 50% or chronic stable angina or FEV1 ≤ 65% or DLCO ≤ 65% or creatinine clearance \<45 ml / min; or liver damage with total bilirubin\> 1.5 N or other comorbidities that the hematologist considers incompatible with intensive treatment * ineligible for a classic allogeneic hematopoietic stem cell transplant due to the presence of co-morbidities or too high a risk of toxicity \>70 years old or at least one of the following comorbidities: PS ≥ 2 or a history of heart failure requiring treatment or LVEF ≤ 50% or chronic stable angina or FEV1 ≤ 65% or DLCO ≤ 65% or creatinine clearance \<45 ml / min; or liver damage with total bilirubin\> 1.5 N * may receive chemotherapy with hypomethylating agents have a partially compatible (haplo-identical) major family donor (≥18 years old) eligible for lymphocyte donation. Exclusion Criteria: * AML with favorable karyotype (according to ELN 2017) in RC1 * Patient with refractory or progressive AML * Other progressive cancer in progress * Karnosky index \<60% or PS\> 2 * Severe hepatic function disturbance: transaminases\> 5 N, hyperbilirubinemia\> 30 µm / L * Severe infection requiring hospitalization. * Psychiatric illness compromising the understanding of the information or the carrying out of the study. * woman of childbearing potential and refusing an effective method of contraception. * Minor * Adult under tutorship or curatorship, under legal protection or under family authorization * Minor family donor (\<18 years old)