Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial

Inclusion Criteria: * Patient who has provided written and informed consent * Adult patient * Patient undergoing cardiac surgery which is: 1. Scheduled 2. With bypass surgery 3. Of the following types: aortic valve surgery, mitral valve surgery, tricuspid valve surgery, atrial myxoma, coronary artery bypass surgery, aortic surgery, combined surgery Exclusion Criteria: * Person not affiliated to national health insurance * Person under legal protection (curatorship, guardianship) * Person under court order * Pregnant or breastfeeding woman * Adult unable to express consent * Patient already included once in the study * Patient requiring emergency surgery within 24 hours * Patients with hypersensitivity to local anesthetics or opiates or to any of the excipients in the products used * Patients on antidepressants, neuroleptics such as non-selective MAOIs (iproniazid), selective A MAOI (moclobemide), selective B MAOI (selegiline) gabapentin (Neurontin®) * Patients with an unprotected atrioventricular conduction disorder * Patients with a prolonged QTc (\> 450 ms) on preoperative ECG * Patient with severe liver failure (PT\< 30%) * Patient suffering from respiratory failure (Long-term oxygen therapy patient except OSA) * Patient with uncontrolled epilepsy * Patient with preoperative cognitive dysfunction (MMS \<24) * Patient with intracranial hypertension * Patient with chronic kidney failure (dialysis, creatinine \> 200 μmol L-1) * Patient with porphyria * Patients treated with linezolid (Zyvoxid®) * Patients with severe arterial hypotension (systolic BP\<90 mmHg)