Pharmacokinetics of Sotorasib in Healthy Participants and Participants With Moderate or Severe Hepatic Impairment

Key Inclusion Criteria All Participants * Participant has provided informed consent before initiation of any study-specific activities/procedures * Participants between 18 and 70 years of age * Body mass index between 18 and 38 kg/m\^2 * Females of nonchildbearing potential defined as permanently sterile or postmenopausal Participants with Normal Hepatic Function * In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, vital signs measurements, and clinical laboratory evaluations Participants with Hepatic Impairment * Child-Pugh B or C classification with clinical laboratory values and clinical examination findings * Documented medical history of chronic liver disease Key Exclusion Criteria All Participants * Female participants with a positive pregnancy test at Screening or Check-in * Male participants with a pregnant partner or partner planning to become pregnant who are unwilling to practice abstinence or use a condom for 7 days after dosing * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance * Participant has received a dose of an investigational drug (new chemical entity) within the past 30 days or 5 half-lives, whichever is longer, prior to Check-in * Use of any over-the-counter or prescription medications within 30 days or 5 half-lives (whichever is longer) * All herbal medicines vitamins, and supplements consumed by the subject within the 30 days prior to enrollment * Alcohol consumption from 48 hours prior to Check-in * Positive test for illicit drugs, cotinine (tobacco or nicotine use), and/or alcohol use at Check-in * Positive human immunodeficiency virus test at Screening Participants with Normal Hepatic Function * Positive hepatitis B or hepatitis C panel at Screening. Subjects whose results are compatible with prior immunity (vaccination or prior infection) may be included * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> upper limit of normal (ULN) at Screening or Check-in * Total bilirubin levels \> ULN at Screening or Check-in * A QT interval corrected for heart rate based on the Fridericia correction (QTcF) interval \> 450 msec in male subjects or \> 470 msec in female subjects or history/evidence of long QT syndrome at Screening or Check-in, confirmed by calculating the mean of the original value and 2 repeats Participants with Hepatic Impairment * Values outside the normal range for liver function tests that are not consistent with their hepatic condition, as determined by the Investigator (or designee) * A QTcF interval \> 470 msec in male subjects or \> 480 msec in female subjects at Screening or Check-in, confirmed by calculating the mean of the original value and 2 repeats * Use of a new medication, or a change in dose, for the treatment, or worsening of, hepatic encephalopathy within 30 days prior to Check-in * Presence of a portosystemic shunt * Evidence of severe ascites