A Study of Sitravatinib Alone or in Combination with Other Anticancer Therapies in Advanced or Metastatic Malignancies
Sitravatinib is a spectrum-selective receptor tyrosine kinase (RTK) inhibitor that inhibits several closely related RTKs including the TAM family (Tyro3/Axl/MERTK), VEGFR2, KIT, and MET. The current study is designed to allow continued access to sitravatinib and to evaluate the safety and tolerability of sitravatinib alone or in combination with other anticancer therapies in patients who are deriving clinical benefit in a previous parent clinical trial.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
52
Sitravatinib is a small molecule inhibitor of receptor tyrosine kinases.
Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody
Pembrolizumab is a programmed death receptor-1 (PD-1) blocking antibody
Rocky Mountain Cancer Centers - Littleton
Littleton, Colorado, United States
Local Institution - 516-014-029
Goshen, Indiana, United States
Local Institution - 516-014-002
Frequency of subjects experiencing treatment-related AEs.
Frequency of subjects experiencing treatment-related AEs.
Time frame: 24 Months
Time to clinical or radiographic progression on study.
Time to clinical or radiographic progression on study.
Time frame: 24 Months
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Enfortumab is a Nectin-4 directed antibody-drug conjugate (ADC) comprised of a monoclonal antibody conjugated to the small molecule microtubule disrupting agent, monomethyl auristatin E (MMAE)
Ipilimumab is a CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) blocking antibody
Boston, Massachusetts, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States
Local Institution - 516-014-005
Minneapolis, Minnesota, United States
Urology Cancer Center and GU Research Network
Omaha, Nebraska, United States
Local Institution - 516-014-011
Albany, New York, United States
Memorial Sloan Kettering Cancer Center - Arnold and Marie Schwartz Cancer Research Building
New York, New York, United States
Local Institution - 516-014-004
Columbus, Ohio, United States
Local Institution - 516-014-001
Austin, Texas, United States
...and 3 more locations