Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

RenJi Hospital200 enrolled

Overview

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status. This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Peritoneal Dialysis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients are Han Chinese; 2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization; 3. Patients successfully complete the first peritoneal equilibration test(PET); 4. Follow up regularly in our PD center. Exclusion Criteria: 1. Patients from hemodialysis to peritoneal dialysis; 2. Patients who need peritoneal dialysis due to transplant-renal loss;

Locations (1)

Renji Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

The relationship between VEGF and KDR Gene polymorphisms and initial transport status in peritoneal dialysis

According to the 4h dialysate over plasma ratio for creatinine （D/P Cr） within three months of starting PD therapy, patients were divided into high transport(H) or high average transport(HA) (H/HA) group and low transport(L) or low average transport(LA) (L/LA) group. Gene polymorphisms of selected VEGF and KDR SNPs were analyzed using extracted blood DNA from these patients. We aimed to investigate the relationship between VEGF and KDR gene polymorphisms and initial peritoneal transport property.

Time frame: For each patient, the outcome would be cross sectional measured at the time the patient does first/initial Peritoneal Equilibration Test. The data collection time period of the study is within 3 months.