Comparison of the Effect of Cervical Mucus Cleaning Method Applied Before Embryo Transfer on Pregnancy Rates.

Zeynep Kamil Maternity and Pediatric Research and Training Hospital183 enrolled

Overview

To assess the impact of cervical mucus cleansing before embryo transfer and compare two different instruments for this purpose.

All patients will be informed about the study and those who give written consent will be included in the study. Women undergoing good quality embryo transfer will be assigned to one of the 3 arms of the study according to the previously determined randomization chart. The first evaluation of the patient will be made on the 12th day after embryo transfer. Pregnancy status will be evaluated with serum βhcg value. If pregnancy is confirmed by serum βhcg value, fetal viability will be evaluated by ultrasound 4 weeks after transfer.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

183

Conditions

Infertility

Interventions

Cotton swabPROCEDURE

Removal of the cervical mucus with a cotton swab before embryo transfer.

CannulaPROCEDURE

Removal of the cervical mucus with a cannula before embryo transfer.

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 21-40 years old women, * Women undergoing good quality embryo transfer, * Women who are eligible for a single or double embryo transfer. Exclusion Criteria: * If there is a diagnosis of a uterine anomaly, * If there is a diagnosis of myoma uteri, * If there is a diagnosis of rheumatological disease, * Women to be transferred other than good quality embryo, * Hİstory of previous pelvic, gynecological operation.

Locations (1)

Zeynep Kamil Women and Children's Diseases Training and Research Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Detecting pregnancy after embryo transfer.

Confirmation of pregnancy with serum βhcg value at the earliest 12th day after embryo transfer.

Time frame: 12 days after embryo transfer/ intervention.

Confirmation of fetal cardiac activity in detected pregnancy.

Evaluation of fetal cardiac activity on ultrasound.

Time frame: 3-4 weeks after embryo transfer/ intervention.

Secondary Outcomes

Success of embryo transfer during intervention.

In some cases, the embryo is transferred to the endometrial cavity and comes back with the transfer cannula. For this reason, the embryology laboratory checks the transfer cannula after the transfer. If the embryo is still in the embryo transfer cannula, a second attempt is made for embryo transfer. As a secondary outcome, we will evaluate the success in the first attempt for embryo transfer.

Time frame: 5 minutes after embryo transfer.

Data from ClinicalTrials.gov

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