An open label, 2-part, one-sequence, 3-period study to evaluate drug-drug interactions between DWN12088 and Pirfenidone or Nintedanib in healthy volunteers
This clinical trial is an open label, 2-part, one-sequence, 3-period study to evaluate drug-drug interactions between DWN12088 and Pirfenidone or Nintedanib in healthy volunteers
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
48
Prolyl-tRNA synthetase (PRS) inhibitor
Pirfenidone
Nintedanib
Cha Unitersity Bundang Medical Center
Seongnam-si, South Korea
Cmax of Pirfenidone and DWN12088
Cmax of Pirfenidone and DWN12088
Time frame: 0hour (pre-dose), 1hour, 2hour, 3hour, 4hour, 6hour, 8hour, 10hour, 12hour
AUC of Pirfenidone and DWN12088
AUC of Pirfenidone and DWN12088
Time frame: 0hour (pre-dose), 1hour, 2hour, 3hour, 4hour, 6hour, 8hour, 10hour, 12hour
Cmax of Nintedanib and DWN12088
Cmax of Nintedanib and DWN12088
Time frame: 0hour (pre-dose), 1hour, 2hour, 3hour, 4hour, 6hour, 8hour, 10hour, 12hour
AUC of Nintedanib and DWN12088
AUC of Nintedanib and DWN12088
Time frame: 0hour (pre-dose), 1hour, 2hour, 3hour, 4hour, 6hour, 8hour, 10hour, 12hour
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