Impact of Oxygen Therapy on Fatigue in Patients With Hypermobile-type Ehlers-Danlos Syndrome

Inclusion Criteria: * Aged ≥ 18 years; * Diagnosed with EDS/HT defined by the New York critieria; * With intense fatigue defined by an FSS ≥ 4; * Having given free and informed written consent; * Speaking french language; * Being affiliated with or benefiting from a social security scheme. Exclusion Criteria: * with progressive parenchymal pulmonary pathology (pulmonary fibrosis, post-smoking emphysema); * having an ongoing pregnancy or breastfeeding; * who have already received oxygen therapy for the EDS / HT indication in the last 6 months; * having a pathology that causes fatigue, which is not compensated or treated; non-exhaustive list anemia, sleep apnea syndrome, psychiatric pathologies including severe depression, organ failure (cardiac, renal, respiratory, hepatic), endocrinopathies (hypo or hyperthyroidism, diabetes), nutritional deficiencies; * Subject to a measure for the protection of justice.