A Randomised, Cross-over, Relative Bioavailability Study of Nicotine Delivery and Nicotine Extraction From Oral Products

Inclusion Criteria: * Body Mass Index (BMI) ≥ 18.0 and ≤ 30.0 kg/m * Clinically normal medical history, physical findings, vital signs, ECG and laboratory values at the time of screening, as judged by the Investigator * Dual user of snus and conventional cigarettes for ≥1 year, with a minimum weekly consumption of two or more snus cans and \>5 cigarettes, and who is willing and able to use brands with nicotine content ≥1% Exclusion Criteria: * History of any clinically significant disease or disorder * Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first use of IP * Positive for HIV, hepatitis B or C * After 10 minutes supine rest at the time of screening, any vital signs values outside the following ranges: * Systolic blood pressure \<90 or \>140 mmHg, or * Diastolic blood pressure \<50 or \>90 mmHg, or * Pulse \<40 or \>90 bpm * Alcohol or drug abuse * Use, or history of use of anabolic steroids * Allergy/hypersensitivity to drugs with a similar chemical structure or class to nicotine * Excessive caffeine consumption (daily intake of \>5 cups) * Female subjects who are pregnant or breastfeeding