This study aims to assess the effects of progressive resistance training compared with aerobic training, among those with hemophilia. Participants will be divided into two groups. The control group will receive an aerobic exercise protocol, and the resistance group will follow a resistance training program. Each group will receive a total of eight sessions. Target muscles are deltoids, biceps, triceps, quadriceps, hamstrings, and calves. Subjective and objective assessment will be performed for each group, to determine the effectiveness of each intervention.
Participant's height, weight and age will be recorded for pre-test anthropometric data. Height will be measured using a stadiometer, and weight will be measured with an electronic scale. Treatment sessions will be conducted twice a week, for 8 weeks. The control group will be administered a standard physical therapy intervention program which will consist of active muscle stretching and aerobic exercises. Exercises will include: * Flexion, extension and abduction at the shoulder joint for anterior, middle and posterior fibers of deltoid * Flexion and extension at the elbow for biceps and triceps trachii * Flexion and extension at the knee joint for quadriceps and hamstring muscles * Plantar flexion at the ankle joint for gastrocnemius and soleus Three sets of ten repetitions of each exercise will be done. The intervention group will undergo a progressive resistance training program consisting of active muscle stretching and resistance training. Exercise for intervention group will consist of: * Resisted flexion, extension and abduction at the shoulder joint for anterior, middle and posterior deltoid, using dumbbells * Resisted flexion and extension at the elbow for biceps and triceps trachii, using dumbbells * Resisted flexion and extension of knee joint for quadriceps and hamstring muscles, using therabands * Resisted dorsiflexion and plantar flexion of gastrocnemius and soleus, using therabands Resistance will be increased on basis of progressive overload principle. Three sets of ten repetitions will be performed per muscle group. Initial weight of the dumbbells will be 1kg and will be increased by 0.5kg per week. Therabands used will be Yellow, Red, Green and Blue. Resistance for therabands will be upgraded every two weeks. Treatment time per group will be approximately 40 minutes. Exercises will be progressed in a gradual manner to give participants time to build muscle strength.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
60
Resistance training of upper limb and lower limb muscles. Resistance will be increased on a weekly basis. Dumbbells and therabands will be used to provide resistance.
The control group will be administered a standard physical therapy intervention program which will consist of active muscle stretching and aerobic exercises.
Hemophilia welfare society karachi
Karachi, Sindh, Pakistan
Manual Muscle Testing - Daniel & Worthingham's
An objective marker to determine muscle strength. It ranges from 0-5 0 no movement of muscle 1. flickering movement of muscle 2. full range of motion in a gravity minimized position 3. full range of motion against gravity, without resistance 4. muscle can hold against moderate resistance 5. muscle can hold against maximal resistance
Time frame: baseline and post intervention (week 8 - the analysis will be conducted on the first week immediately after the end of the training)
Hemophilia Joint Health Score (HJHS v2.1)
The HJHS measures joint health, in the domain of body structure and function (i.e. impairment), of the joints most commonly affected by bleeding in hemophilia: the knees, ankles, and elbows. It can be used when there is a need for orthopedic intervention, or as an outcome measure of physiotherapy interventions. A scoring system is present, which combines the score of these questions, with a global gait score, to give an overall score. The greater the score, the poorer the outcome. The HJHS 2.1 provides a total score (higher score is worse; max=124), joint specific scores, and a global gait score.
Time frame: baseline and post intervention (week 8 - the analysis will be conducted on the first week immediately after the end of the training)
Borg Rating of Perceived Exertion
The second subjective marker. This will be used to assess the subjective workload of exercises, and to note if exercise intensity decreases over time. The values range from 6-20, with 6 rated as 'no exertion', and 20 rated as 'maximal exertion'.
Time frame: baseline and post intervention (week 8 - the analysis will be conducted on the first week immediately after the end of the training)
HEP-Test-Q (Hemophilia and Exercise Project)
The subjective marker of this study. This measure will assess the quality of life. It is a scale specifically designed for people with hemophilia. The HEP-Test-Q consists of 25 items pertaining to 4 domains 'mobility', 'strength \& coordination', 'endurance' and 'body perception' and one single item, which assesses changes in physical functioning in comparison to the previous year. The recall period for the assessment of physical functioning is over "the past four weeks". The response options range on a 5-point Likert scale from "never" to "always". Some of the items have to be re-coded. Subscales and the total score are transformed to a scale of 0-100 with high scores indicating better physical functioning.
Time frame: baseline and post intervention (week 8 - the analysis will be conducted on the first week immediately after the end of the training)
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