Impact of the Rapid Normalization of Chronic Hyperglycemia and the Practice of Moderate Physical Activity on the "Receptor Activator of Nuclear Factor-kappa B Ligand / Osteoprotégérine (RANKL / OPG) System in Patients Living With Type II Diabetes

Inclusion Criteria: Group G1: * Male or female patient aged 18 to 70, not practicing regular physical activity (Baecke score \<10) * Patient with type 2 diabetes for at least 1 year * Patient treated with metformin +/- SU +/- DPP4 inhibitor +/- GLP1 analogue +/- insulin therapy * Patient insufficiently balanced under his current treatment with an HbA1c level\> 8.5% for 6 months. * Patient able to practice physical activity on a regular basis * Patient having performed a coronary artery disease screening test in the year prior to inclusion * Woman of childbearing age with effective contraception put in place and monitored throughout the trial * Patient having given his consent to participate in the study and having signed an informed consent * Within the G1 group, a controlled 1: 1 randomization, stratified on age (≤65 years or\> 65 years) and BMI (≤ 30 or\> 30) will determine the inclusion of patients in the G1A group (correction of HbA1c) or G1B (correction of HbA1c + physical activity). Group G2: * Male or female patient aged 18 to 70, not practicing regular physical activity * Patient with type 2 diabetes for at least 1 year * Patient treated with metformin +/- SU +/- DPP4 inhibitor +/- GLP1 analogue +/- insulin therapy * Patient balanced under his current treatment with an HbA1c level \<7% for 6 months. * Women of childbearing potential with effective contraception put in place and monitored throughout the trial * Patient having given his consent to participate in the study and having signed an informed consent * Matching with the last patient included in group G1 on age (± 5 years), sex, duration of diabetes (± 2 years) and BMI (± 2kg / m2). Exclusion Criteria: * Fetal and maternal pathologies requiring maturation Patient with type 1 diabetes * Patient with regular physical activity * History of severe cardiovascular pathologies (myocardial infarction, or acute coronary syndrome, or stroke in the past year) * Patient with a history of severe hypoglycemia in the 6 months preceding entry into the study and / or not experiencing hypoglycemia at all * Patient pregnant or likely to be * Severe obesity (BMI\> 35kg / m2) * Other pathologies likely to interfere with the glycemic variation: in particular the use of corticosteroids during the study * Patient already having Charcot's neuroarthropathy or symptomatic autonomic neuropathy: orthostatic hypotension and / or gastro-paresis * Patient with preproliferative diabetic retinopathy * Patient having anti RANKL treatment * Subject under tutorship or curatorship * Subject not affiliated to social security.