Effect of Continuous Invasive Blood Pressure Monitoring on Postinduction Hypotension in Patients Having Major Surgery

Universitätsklinikum Hamburg-Eppendorf242 enrolled

Overview

This is a randomized trial (1) investigating whether continuous invasive arterial blood pressure monitoring using an arterial catheter reduces the area under a mean arterial pressure (MAP) of 65 mmHg within the first 15 minutes of anesthetic induction compared to intermittent arterial blood pressure monitoring using oscillometry in patients having major surgery under general anesthesia; and (2) investigating the effect of continuous invasive arterial blood pressure monitoring using an arterial catheter on cardiac output, stroke volume, and heart rate within the first 15 minutes of anesthetic induction compared to intermittent blood pressure monitoring using upper-arm cuff oscillometry in patients having major surgery under general anesthesia.

not provided

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

242

Conditions

Blood Pressure Perioperative Hypotension Postinduction Hypotension

Continuous invasive blood pressure monitoringDEVICE

Continuous invasive blood pressure monitoring using an arterial catheter

Intermittent non-invasive blood pressure monitoringDEVICE

Intermittent non-invasive blood pressure monitoring using upper-arm cuff oscillometry

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients... * at least 18 years of age * scheduled for elective major surgery under general anesthesia that requires continuous invasive arterial blood pressure monitoring using a radial arterial catheter for clinical indications not related to the study Exclusion Criteria: * Clinical indication to insert the arterial catheter before anesthetic induction ("awake arterial catheter"; this is usually the case in patients with severe cardiovascular diseases, such as heart failure or left ventricular assist device) * emergency surgery * American Society of Anesthesiologists physical status classification V or VI * need for femoral artery catheterization * heart rhythms other than sinus rhythm.

Outcomes

Primary Outcomes

Area under a MAP of 65 mmHg within the first 15 minutes of anesthetic induction between the intervention and the control group.

Time frame: during the induction period

Secondary Outcomes

Effect of continuous invasive arterial blood pressure monitoring on cardiac output within the first 15 minutes of anesthetic induction between the intervention and the control group.

Time frame: during the induction period

Effect of continuous invasive arterial blood pressure monitoring on stroke volume within the first 15 minutes of anesthetic induction between the intervention and the control group.

Time frame: during the induction period

Effect of continuous invasive arterial blood pressure monitoring on heart rate within the first 15 minutes of anesthetic induction between the intervention and the control group.

Time frame: during the induction period

Effect of Continuous Invasive Blood Pressure Monitoring on Postinduction Hypotension in Patients Having Major Surgery

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes