Immune Response to SARS-CoV-2 Vaccination in Systemic Lupus

University Hospital, Strasbourg, France7 enrolled

Overview

The main objective is to study the impact of vaccination against Covid-19 on the specific humoral and cellular immune response (against SARS-CoV-2) and non-specific (evolution of the pathological immune system of the disease), in a lupus population. The secondary objective is to study the impact of lupus disease activity on the humoral and cellular response of patients following vaccination against SARS-CoV-2. The hypothesis is that disease activity and / or certain treatments used in lupus may interfere with the humoral and cellular immune response induced by vaccination against SARS-CoV-2.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus

Interventions

SRAS-CoV-2 vaccination immunological responseBIOLOGICAL

Follow for 18 months a single group of 30 patients with systemic lupus after their SRAS-CoV-2 vaccination. Intervention includes immunological analysis on additional volume of blood collected as part of routine care.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult subject (≥ 18 years old), male or female * Patient with systemic lupus according to ACR 1997 criteria * Patient followed by the National Reference Center "Rare Systemic Autoimmune Diseases" of the University Hospitals of Strasbourg * Patient who agreed to be vaccinated against SARS-CoV-2 * Subject having expressed his non-opposition to the research * Subject affiliated to a social health insurance protection scheme Exclusion Criteria: * Patient treated by: * Corticosteroids (\> = 10mg / day) * Immunosuppressant (azathioprine, mycophenolate mofetil, cyclophosphamide) to control lupus activity * A biomedicine targeting B cells (rituximab, belumimab). * Inability to provide informed information about the subject (subject in an emergency, difficulty in understanding the subject, etc.) * Subject under safeguard of justice * Subject under guardianship

Locations (1)

University Hospital of Hautepierre

Strasbourg, Bas-Rhin, France