To design and understand the mechanism of action of different combinations of nutraceuticals coupling bacteria, fibers and polyphenols, which can act on the 4 pillars simultaneously via an innovative ex-vivo model approach coupled with functional and quantitative metagenomics.
The objective of the study is to collect fresh stools from 4 healthy volunteers, in order to study the mechanism of action of probiotic strains, polyphenols and fibers, alone or in combinations. These fresh stools will be cultured in vitro in fermenters, and the samples taken at different culture times will be analyzed in terms of microbial composition (shotgun metagenomic analysis) and their cellular activity (functional metagenomic analysis).
Study Type
OBSERVATIONAL
Enrollment
4
Fresh stools will be cultured in vitro in fermenters with adjunction of probiotic strains
Fresh stools will be cultured in vitro in fermenters with adjunction of polyphenols
Fresh stools will be cultured in vitro in fermenters with adjunction of fibers
Bacterial growth
Change about the bacterial growth after 15 days of incubation
Time frame: Day 1 to Day 15
PH evolution
Change about the PH evolution after 15 days of incubation
Time frame: Day 1 to Day 15
Quantity of Co2 production
Change about the quantity of Co2 production after 15 days of incubation
Time frame: Day 1 to Day 15
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.