Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients

Pontificia Universidad Catolica de Chile47 enrolled

Overview

The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Radiotherapy; Complications Cardiotoxicity Cancer Lung Cancer Breast Cancer Esophageal Cancer

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥18 year-old patients * With histologically confirmed thoracic cancer (breast, esophagus or lung) * Recommendation of thoracic radiotherapy (RT) with curative intent * With or without chemotherapy * All patients must be able to read and understand Spanish * All patients must sign informed consent form. Exclusion Criteria: * Patients with no medical records, * Pregnant * Previously diagnosed with severe left ventricular dysfunction or a cardiac insufficiency * Patients with metastatic disease and indication of palliative RT * Patients with significant comorbidities associated to a \<5 year life expectancy. * Patients previously treated with thoracic RT

Outcomes

Primary Outcomes

Global Longitudinal Strain (Left Ventricle)

\>5 Absolute drop or 12% Relative reduction from baseline

Time frame: Baseline, 1 and 12 weeks after Treatment

Secondary Outcomes

Cardiac Magnetic Resonance Cinema Imaging

Cinema imaging: Long axis balance, Balance 4 cameras, Short shaft full balance, Right ventricular balance

Time frame: Baseline, 1 and 12 weeks after treatment

Cardiac Magnetic Resonance Anatomical Image

Inversion recovery single shot balance 3D short axis covering the entire heart and aorta with free respiratory trigger

Time frame: Baseline, 1 and 12 weeks after treatment

Cardiac Magnetic Resonance Flow Image

2D outflow tract of the aorta 2D pulmonary artery outflow tract

Time frame: Baseline, 1 and 12 weeks after treatment

Cardiac Magnetic Resonance Quantitative Image

T1 map short axis apical section T1 map short axis medial section T1 map short axis basal section T2 map short axis apical section T2 map short axis medial section T2 map short axis basal section

Time frame: Baseline, 1 and 12 weeks after treatment

Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes