Antiretroviral Speed Access Program

Dr. Bertrand Lebouche75 enrolled

Overview

Migrant populations represent an increasing proportion of newly referred people living with HIV in Canada, particularly in Quebec. Timely HIV care of newly referred patients has important individual-level health benefits that can result in decreased transmission and benefit the society as a whole. Yet, the timing of events in the HIV care cascade (from linkage to care to sustained viral suppression) together with the specific experience of care of these vulnerable populations (asylum-seekers, international students, patients with no status) who often face specific psycho-social and/or financial issues, has rarely been studied. In particular, little is known about their experience of HIV care whether they are referred to a multidisciplinary clinic or a physician-only clinic. In a context where B/F/TAF will be provided free-of-charge to all enrolled participants including migrant populations, we aim to investigate what model of care can best address current deficiencies in the standard HIV care cascade for newly-referred patients, which often involves delays in linkage to care and starting ART.

Study Type

OBSERVATIONAL

Enrollment

Conditions

HIV Infection

Interventions

BiktarvyDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. 18 years or older 2. Newly referred at the study site 3. HIV-1 infected (fourth generation HIV Ag/Ab combination assay) 4. Treatment-naïve to all anti-HIV therapy, except for the use for pre-exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP), up to one month prior to screening 5. Estimated GFR \>30 mL/min/1.73m2 according to the Cockcroft-Gault formula for creatinine clearance 6. Must be willing and able to understand the requirements of study participation and provide signed and dated written informed consent prior to screening 7. Female participants who are willing to use acceptable methods of birth control as defined in the protocol Exclusion Criteria: 1. Have received anti-HIV therapy previously, except for PrEP or PEP taken up to one month prior to screening 2. Viral load \<100 copies/mL, high suspicion of non-reported ART use or being a long-term nonprogressor or elite controller 3. Concomitant use of drugs with contraindication or drug-drug interactions with B/F/TAF 4. Documented historic or baseline allergy to any of the components of B/F/TAF 5. Estimated eGFR (by Cockcroft-Gault formula) \< 30 mL/min 6. Pregnant, breast-feeding or planning or suspected to get pregnant 7. Involvement in any other interventional HIV studies during the study period 8. Has any reason, in the opinion of the investigator, which would make the candidate inappropriate for participation in an investigative study involving oral medications

Outcomes

Primary Outcomes

Change in perceived problem solving

Subscale of the Patient-Assessment of Chronic Illness Care (PACIC) measure. The PACIC consists of 5 scales and an overall summary score. Items 12 to 15 are about "Problem Solving/Contextual"; each can be scored from 1 to 5 (higher scores mean a better outcome and lower scores mean a worse outcome).