Left Bundle Branch Block (LBBB) After IntuityTM

Assistance Publique Hopitaux De Marseille274 enrolled

Overview

This study aimed to evaluate incidence, prognosis and predictive factors of new-onset of persistent left bundle branch block (LBBB) after rapid-deployment aortic valve replacement (RD-AVR) with the IntuityTM bioprosthesis. It was an observational, retrospective and single-center study. Two hundred and seventy-four consecutive patients without any baseline ventricular conduction disorder or previous permanent pacemaker or defibrillator implantation who underwent RD-AVR with the IntuityTM valve were included. Twelve-lead electrocardiogram and transthoracic echocardiography were performed preoperatively, postoperatively, at discharge, 1-month, and 1-year. Incidence, prognosis and predictive factors of new-onset of persistent LBBB were evaluated.

Study Type

OBSERVATIONAL

Enrollment

274

Conditions

Aortic Valve Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * rapid-deployment aortic valve replacement (RD-AVR) with the Edwards Intuity™ bioprosthesis for severe aortic valve stenosis * between July 2012 and May 2018 Exclusion Criteria: * preoperative permanent pacemaker or defibrillator, * complete intraventricular conductive disorder defined by a QRS width ≥ 120 ms. * absence of patient's authorization for anonymous publication of their clinical data for research purposes.

Locations (1)

Assistance Publique Hôpitaux de Marseille

Outcomes

Primary Outcomes

Incidence of NOP-LBBB (new onset of persistent left bundle branch block)

QRS duration ≥ 120 ms with QS or rS patterns on the V1 lead, a large notched R wave in D1, aVL, V5 and V6 and the absence of Q wave in V5 and V6, according to the recommendations of the American Heart Association. NOP-LBBB was persistence of LBBB on the 12-lead recording electrocardiogram (ECG) at discharge from hospital.

Time frame: at 1 year