Serological Response to mRNA and Inactivated COVID-19 Vaccine in Health Care Workers in Hong Kong

Hong Kong Sanatorium & Hospital480 enrolled

Overview

Since the first local case of COVID-19 confirmed on 4 Feb 2020, Hong Kong has already experienced 4 waves of COVID-19 surge, with more than 9000 cases reported. A number of vaccines have been shown to be efficacious against symptomatic and severe infection by inducing neutralizing antibody (NAB) against spike protein of the SARS-CoV-2 virus. However, the duration of protection and longevity of antibody response is unknown. Health care workers (HCWs) who are planning to receive COVID-19 vaccine will be recruited. The level of antibody against spike protein by different quantitative assays will also be serially measured .

Study Type

OBSERVATIONAL

Enrollment

480

Conditions

Covid-19 Vaccine

Interventions

CoronaVac VaccineBIOLOGICAL

CoronaVac Vaccine

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Any staff, visiting doctor, nursing student of HKSH who are aged 18 or above 2. No contraindication for COVID-19 vaccination and plan to receive the intended dosages at the appropriate interval. 3. A baseline serology taken within 1 week before vaccination shows no evidence of recent infection. 4. No history of documented COVID-19 infection Exclusion Criteria: \-

Outcomes

Primary Outcomes

Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine

Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine at different points during the first six months of vaccination

Time frame: 1 month, 3 months and 6 months post vaccination