A Study to Investigate the Pharmacokinetics of ACT-1014-6470 in Subjects With Severe Renal Impairment Compared to Control Subjects

Inclusion Criteria: * Signed informed consent in a language understandable to the subject prior to any study-mandated procedure. * Male or female subject aged at least 18 years at Screening. * Women of non-childbearing potential (e.g. post-menopausal) Additional inclusion criteria for subjects with severe renal impairment (Group A). \- Severe renal function impairment as confirmed at Screening based on an estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula of \< 30 mL/min (not on dialysis). Additional inclusion criteria for control subjects (Group B): * Normal renal function as confirmed at Screening based on eGFR. * Each control subject must be matched to the values of one subject with severe renal impairment based on age (±10 years difference allowed), BMI (±15% difference allowed), and sex, determined by results at Screening. Exclusion Criteria: \- Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol.