ACOART SCB BIF: Treatment of Coronary Bifurcation Lesion by Sirolimus Coated Balloon vs Paclitaxel Coated Balloon

Inclusion Criteria: * Age ≥18 years old and ≤75 years old * Diagnosed as stable or unstable angina pectoris, asymptomatic myocardial ischemia or old myocardial infarction, or recent myocardial infarction in stable stage. * Eligible for balloon dilatation or stent implantation. * Subject (or legal guardian) understands the study requirements and procedures and provides written Informed Consent before any study tests or procedures are performed Exclusion Criteria: * AMI occurred within 7 days before operation * The subjects had congestive heart failure or the heart function was classified as NYHA/KillipIV. * Left ventricular ejection fraction (LVEF) \< 35% * History of heart transplantation * The subjects had severe arrhythmias, such as high-risk ventricular extrasystole and / or ventricular tachycardia. * The subjects had stroke, gastrointestinal bleeding or active ulcers, or had a high risk of bleeding in the past 6 months. * Active bleeding physique or blood coagulation disorder * Known renal insufficiency（eGFR\<30ml/min） * Contraindicated to anticoagulants or antiplatelet agents * Has a history of percutaneous coronary intervention (PCI) within 6 months before enrollment. * Has contraindications for coronary artery bypass grafting * known to be allergic to aspirin, heparin, contrast agents, paclitaxel and sirolimus * Life expectancy less than 12 months, or unable to complete a 12-month follow-up * Pregnant or lactating females, or who plan to become pregnant during a follow-up period of 1 year after operation * The subjects have participated in other drug property studies or device studies that have not yet completed the main end point. Angiographic Inclusion Criteria: * One target lesion (bifurcation lesion) in the coronary artery is allowed, and if there are coexistent non-bifurcated lesions requiring PCI intervention, only one lesion was accepted at most, and the target lesion should be treated after successful PCI treatment of non-target lesion. * Target Lesion located in native coronary artery must be de novo * Medina classification should be (1.1.1, 1.0.1, 0.1.1) * Main branch of target lesion (%DS is ≥70% or ≥50% with clinical symptoms ) is suitable for stent implantation * Target Lesion located in main branch should be covered by DES. Moreover, the residual stenosis ≤ 30%, TIMI flow is 3, no complications and branch vessel opening stenosis ≥ 70%. * Reference vessel diameter of the branch is 2.0-4.0mm (by visual) * Target lesion length ≤ 36mm (by visual) Angiographic Exclusion Criteria: * Target or non-target lesion located in left main * Subjects who have non-target lesions of bifurcation * The target lesion is trifurcation or multifurcation lesion. * Main branch of target lesion located within 3 mm from the ostium of LAD or LCx or RCA * The branch lesion is a diffuse long lesion, which could't covered by one DCB. * Main or side branch is occlusive lesion, which TIMI flow is 0. * Aneurysm existed in the blood vessel at the target lesion * Side branch severely calcified or tortuous * The blood pressure was too low to tolerate intracoronary injection of ≥ 100ug nitroglycerin * Failure pre-dilatation of the side branch ostium (residual stenosis \> 30% ,the blood flow in TIMI is not up to grade 3, or has dissection of type C or above according to NHLBI grade)