Intracranial Pressure Monitoring in Moderate Traumatic Brain Injury

Inclusion Criteria: * History of head trauma * 18 ≤ age ≤ 70 years * Abnormal head CT scan (skull fracture, intracranial hematoma, brain contusion, cerebral infarction, brain edema, hydrocephalus, etc.) * Glasgow coma scale at admission: 9-12 * Arriving at hospital within 24 hours after injury * Systolic blood pressure ≥100 millimeter of mercury * No pregnant Exclusion Criteria: * Refusing follow up visit * Penetrating head injury, spine or spinal cord injury * Surgical treatment in other hospital before admission * Cardiopulmonary resuscitation after injury or in need of blood transfusion due to active bleeding * Consciousness disorder caused not by head trauma (alcoholism, drug overdose, etc.) * Prior history of head trauma or stroke * Multiple injuries, with severity score of other parts\>18 * Rhabdomyolysis, with blood creatine kinase (CK)\>5000 international unit/L * Injury of aorta, carotid artery or vertebral artery * Serum creatinine (female)\>1.2mg/dL (106μmol/L), serum creatinine (male)\>1.5mg/dL (133μmol/L) * Glomerular filtration rate (eGFR) \<60 milliliter/min * Body mass index (BMI) \<18.5kg/m2 or \>40kg/m2 * Estimated survival time less than 1 year * Participating in other on-going clinical researches * Other systemic diseases: uremia, liver cirrhosis, malignant tumor, mental illness, drug, or alcohol dependence, etc.