Since the beginning of the COVID-19 pandemic, nasopharyngeal swabs (NPS) have been recommended to detect the virus. This procedure has been reported to be painful by 85% of children The aim of the study was to assess whether pretreatment with topical lidocaine reduces the discomfort experienced by children during a nasopharyngeal swab. This was a RCT among children aged 8-17 years old who need a NPS. The primary outcome was pain intensity as measured by the Visual Analog Scale .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
88
The study intervention was the administration of 10 mg of intranasal lidocaine in one nostril using 1 spray of 0.1mL of a 10% lidocaine solution 5 minutes before NPS. This was done using the standard long nozzle
The control group received the placebo with the same application technique using an empty bottle of lidocaine 10% with the same long nozzle for delivery
Evelyne D Trottier
Montreal, Quebec, Canada
Pain during the procedure
Self-reported pain immediately after the NPS as measured using a validated self-reported pain scale: the Visual Analog Scale (VAS
Time frame: During procedure
Anxiety during the procedure
● Evaluation of fear prior to the administration of the study intervention and the NPS using the Children's Fear Scale
Time frame: During procedure
Discomfort
Discomfort at administration of the study intervention using a yes/no question
Time frame: During procedure
Pain 2 NRS
Evaluation of pain immediately after the NPS using a clinically relevant tool, the verbal Numeric Rating Scale
Time frame: During procedure
Number of patients with physical restriction
Evaluation of the patient position (sitting, lying down, standing) and if physical restraints was done (none, redirection of movements, comfort position/minimal comfortable restriction or actively restrain) to perform the swab and to which extent
Time frame: During procedure
Utility according to nurses
● Triage nurses evaluation on the efficiency of the intervention in reducing pain in the patient, using a likert scale of 1 to 5
Time frame: During procedure
Adverse event
Adverse effects reported by caregivers in the 24-48hrs following administration of medication
Time frame: 48 hours following intervention
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Desire to reuse the intervention in a futur procedure, at follow up
Asking caregivers in the 24-48hrs following intervention if they would recommend the intervention before a NPS as standard of care for pediatric patients. Yes/no question.
Time frame: 48 hours following intervention