The purpose of this study is to understand changes of the gut microbiome due to esophageal atresia. The intervention will be to give a patient his or her own saliva through their gastrostomy tube (directly into the stomach) to observe if this can normalize microbial colonization of the gut.
After being informed about the study and its overall risks, parents will be given the option to enroll their infant. Participants (infants) with esophageal atresia and a gastrostomy tube will be given their own saliva through their gastrostomy tube, directly into the stomach. Samples of saliva and stool will be collected from these infants, and from a comparison group without esophageal atresia, as well as blood and urine to look for changes in immune responses and in metabolism.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
52
Infants with esophageal atresia will be given their own saliva
Lucile Packard Children's Hospital
Palo Alto, California, United States
Change in Gut Microbial Community Structure
Evaluate community structure and differential abundances of dominant taxa and of key taxa to the newborn (e.g., Bifidobacterium, Bacteroides, Lactobacillus, Staphylococcus and Enterobacteriaceae)
Time frame: From birth until discharge from the hospital, up to 1 year
Change in Immune System Profile
Determine immune cell profiles using mass cytometry (CyTOF)
Time frame: From birth until discharge from the hospital, up to 1 year
Change in Fecal Metabolome Profile
Measure metabolites in the stool using mass spectrometry
Time frame: From birth until discharge from the hospital, up to 1 year
Change in Blood Metabolome Profile
Measure metabolites in the blood using mass spectrometry
Time frame: From birth until discharge from the hospital, up to 1 year
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