The aim of this pilot study is to understand the biological changes that occur within the knee joint following injury to the anterior cruciate ligament (ACL). This will be achieved through aspiration and analysis of the haemarthrosis which fills the knee following injury. The study will look at inflammatory and healing responses using DNA, RNA and protein analysis. This, combined with high resolution imaging of the knee and surrounding soft tissue structures, may enable a more patient specific approach to treatment of ACL injury.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
5
Aspiration of haemarthrosis and high definition MRI
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
RECRUITINGPattern of injury on High Definition MRI measured by comparison with 3t MRI images
Outcome will illustrate any additional benefit of high definition MRI
Time frame: Last visit, usually 28 days
Identification of acute inflammatory mediators measured by NanoString molecular analysis
Time frame: Last visit, usually 28 days
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