It is important to estimate the adequate dose of remimazolam intravenous bolus injection to induce the loss of consciousness. We will determine the ED50 and ED95 of remimazolam intravenous bolus on the loss of consciousness in patients undergoing general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
120
Remimazolam of 0.02 mg/kg will be infused in patients aged\<65.
Remimazolam of 0.07 mg/kg will be infused in patients aged\<65.
Remimazolam of 0.12 mg/kg will be infused in patients aged\<65.
Gangnam Severance Hospital
Seoul, South Korea
Loss of consciousness within 5 minutes
Loss of consciousness will be evaluated at 5 minutes after infusion.
Time frame: At 5 minutes after infusion
Time to loss of consciousness
Time to loss of consciousness will be assessed at 5 minutes after infusion.
Time frame: At 5 minutes after infusion (time to loss of consciousness)
blood pressure
Blood pressure will be measured at 0, 1, 2, 3, 4, 5 minutes after infusion.
Time frame: At 5 minutes after infusion
heart rate
Heart rate will be measured at 0, 1, 2, 3, 4, 5 minutes after infusion.
Time frame: At 5 minutes after infusion
sedline
Sedline will be measured at 0, 1, 2, 3, 4, 5 minutes after infusion.
Time frame: At 5 minutes after infusion
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Remimazolam of 0.17 mg/kg will be infused in patients aged\<65.
Remimazolam of 0.22 mg/kg will be infused in patients aged\<65.
Remimazolam of 0.27 mg/kg will be infused in patients aged\<65.
Remimazolam of 0.02 mg/kg will be infused in patients aged≥65.
Remimazolam of 0.07 mg/kg will be infused in patients aged≥65.
Remimazolam of 0.12 mg/kg will be infused in patients aged≥65
Remimazolam of 0.17 mg/kg will be infused in patients aged≥65.
Remimazolam of 0.22 mg/kg will be infused in patients aged≥65.
Remimazolam of 0.27 mg/kg will be infused in patients aged≥65.