A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, Food Effects, and Drug-drug Interactions of ACP-196 in Healthy Participants

Inclusion Criteria: * Body mass index (BMI) \>=18.0 and \<=30.0 kg/m\^2. * Healthy as determined by medical history and physical examination. * Nonsmoker * Normal clinical laboratory test results and ECG, or results with minor deviations which are not considered to be clinically significant in the judgment of the investigator. * Men of and women of childbearing potential to follow protocol defined contraception methods. * Women must have negative urine pregnancy test. * Willingness and ability to swallow study drug capsules. Exclusion Criteria: * Prior or ongoing clinically significant illness, medical condition, medical history, physical findings, ECG findings, or laboratory abnormality that, in the investigator's opinion, could affect the safety of the subject; alter the absorption, distribution, metabolism, or excretion of the study drug; or impair the assessment of study results. * Evidence of ongoing systemic bacterial, fungal, or viral infection (including upper respiratory tract infections). * Women cannot be pregnant or breast feeding. * Significant history of drug or alcohol abuse or addiction within 3 years before study screening or as evidenced by continuing medical complications of prior drug or alcohol use. * History of blood or plasma donation within 90 days before first study drug administration. * Currently drinking over 21 units/week of ethanol * Drug toxicology screen positive for any prohibited drugs, illicit substances, or alcohol. * Anticipated need for alcohol, tobacco, or any drug during the study drug administration and immediate follow-up periods. * Relative to admission has any of the following exposures: has taken a prescription systemic medication within 14 days; has used an over-the counter systemic medication (other than acetaminophen) within 7 days; has ingested calcium supplements or calcium-containing vitamins within 7 days; has ingested grapefruit, grapefruit juice, or grapefruit-containing products within 7 days; has consumed alcohol within 48 hours; has taken acetaminophen within 24 hours. * Positive test for human immunodeficiency virus (HIV) antibody, hepatitis B surface antigen or hepatitis B core antibody, or hepatitis C antibody. * Unwillingness to avoid vigorous physical activity during inpatient clinic confinements. * Part 2 only - Inability or unwillingness to eat all of the ingredients of the high-fat, high-calorie meal as specified in the protocol. * Part 3 only - Known allergy to itraconazole or other azole compounds.