The Effect of tDCS on Motor Learning and Neural Network in Stroke Patients

Samsung Medical Center21 enrolled

Overview

This study is to investigate the effect of transcranial direct current stimulation (tDCS) simulation on motor learning to stroke patients compared to sham stimulation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Stroke

Interventions

Transcranial Direct Current StimulationDEVICE

Transcranial direct current stimulation is a form of noninvasive neuromodulation that uses constant and low direct current delivered via electrodes on the scalp.

Motor learningBEHAVIORAL

Sequential finger tapping task training is applied to stroke patients.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Unilateral stroke including basal ganglia lesion patients * Chronic patients over 6 months after onset * Patients with the movement of fingers Exclusion Criteria: * History of psychiatric disease * Significant other neurological diseases except for stroke * Difficult to perform this experiment * Patients who are deemed difficult to participate in this research by the investigator * Patients with metal implants and medical devices * History of epilepsy * Pregnancy * Skin defect at the site of electrode attachment

Locations (1)

Samsung Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Fugl-Meyer Assessment

The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured.

Time frame: Baseline, immediately after five brain stimulation sessions

Secondary Outcomes

Changes in cortical activity using fNIRS signals during brain stimulation

Cortical activities before, during and after brain stimulation sessions are compared.

Time frame: Baseline, during, immediately after five brain stimulation sessions

Changes in motor evoked potential

Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response.

Time frame: Baseline, immediately after five brain stimulation sessions

9-hole pegboard test

The test is a standardized, quantitative assessment used to measure finger dexterity of a patient.

Time frame: Baseline, immediately after five brain stimulation sessions

Grip & Tip pinch strength test

The test is to measure the maximum isometric strength of hand, forearm, and finger muscles.

Time frame: Baseline, immediately after five brain stimulation sessions

Box & Block test

The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device.

Time frame: Baseline, immediately after five brain stimulation sessions

Data from ClinicalTrials.gov

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