Evaluation of effect on diurnal glycaemia following consumption of MCT and whey protein in patients with type 2 diabetes
The purpose of this study (Combine) is to evaluate the effects of Combined Intake of Medium chain triglycerides (MCT) at breakfast and whey protein isolate (WPI) preload at lunch and dinner for patients with type 2 diabetes
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
22
MCT (Medium chain triglycerides)
Whey Protein Isolate
Iso-voluminous Water as comparitor to Betaquik or WheyBasics
University of Nottingham
Nottingham, United Kingdom
Diurnal glucose Incremental area under curve (iAUC) concentrations
Constant glucose monitoring (CGM) comparing treatment regimen A-B-C
Time frame: 115 days
Glucose concentrations
Mean, standard deviation and coefficient of variation of 24h glucose concentration as 24h 24h assessed by CGM
Time frame: 115 days
Area under curve (AUC) glucose
24h assessed by CGM
Time frame: 115 days
Incremental area under curve (iAUC) glucose
24h assessed by CGM
Time frame: 115 days
Visual Analogue Scale (VAS) questionnaire
100-point VAS on satiety
Time frame: 115 days
Glucose mean
Arterialised blood concentration
Time frame: 115 days
Glucose Incremental area under curve (iAUC)
Arterialised blood concentration
Time frame: 115 days
Leptin mean
Arterialised blood concentration
Time frame: 115 days
Leptin Incremental area under curve (iAUC)
Arterialised blood concentration
Time frame: 115 days
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Gastric inhibitory polypeptide (GIP) - GLP-1 mean
Arterialised blood concentration
Time frame: 115 days
Glucagon-like peptide-1 (GLP-1) mean
Arterialised blood concentration
Time frame: 115 days
Gastric inhibitory polypeptide (GIP) - Incremental area under curve (iAUC)
Arterialised blood concentration
Time frame: 115 days
Glucagon-like peptide-1 (GLP-1) Incremental area under curve (iAUC)
Arterialised blood concentration
Time frame: 115 days
Peptide tyrosine tyrosine (PYY) mean
Arterialised blood concentration
Time frame: 115 days
Peptide tyrosine tyrosine (PYY) Incremental area under curve (iAUC)
Arterialised blood concentration
Time frame: 115 days