To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
35
To investigate the role of levcromakalim compared with placebo in migraine with aura patients
To investigate the role of levcromakalim compared with placebo in migraine with aura patients
Danish Headache Center
Glostrup Municipality, Copenhagen, Denmark
Headache incidence
Difference in incidence of headache following infusion of levcromakalim compared to placebo in patients with migraine with aura.
Time frame: 10 minutes before until 24 hours after infusion of levcromakalim or placebo
Migraine incidence
Difference in incidence of migraine-like headache following infusion of levcromakalim compared to placebo in patients with migraine with aura.
Time frame: 10 minutes before until 24 hours after infusion of levcromakalim or placebo
Aura incidence
Difference in incidence of migraine aura following infusion of levcromakalim compared to placebo in patients with migraine with aura.
Time frame: 10 minutes before until 24 hours after infusion of levcromakalim or placebo
Headache intensity
The area under the curve (AUC) for headache following infusion of levcromakalim compared to placebo in patients with migraine with aura
Time frame: 10 minutes before until 24 hours after infusion of levcromakalim or placebo
Heart rate
Change in heart rate measured in Beats per minute (BPM) following infusion of levcromakalim compared to placebo in patients with migraine with aura
Time frame: 10 minutes before until 120 minutes after infusion of levcromakalim or placebo
Blood pressure
Change in blood pressure (systolic and diastolic) measured in mmHg following infusion of levcromakalim compared to placebo in patients with migraine with aura
Time frame: 10 minutes before until 120 minutes after infusion of levcromakalim or placebo
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