Trial of AD113 and Atomoxetine in OSA Patients With Hypertension

Inclusion Criteria: * Between 25 to 65 years of age, inclusive, at the Screening Visit. * AHI 10 to 50 (hypopneas defined by 4% oxygen desaturation) * History of hypertension or blood pressure at Visit 1 ≥130/80 mmHg Exclusion Criteria: * History of narcolepsy. * Clinically significant craniofacial malformation. * Clinically significant cardiac disease (e.g., rhythm disturbances, coronary artery disease or cardiac failure) or hypertension requiring more than 2 medications for control. A medication for these purposes is defined by dosage form, such that a combination antihypertensive medication is considered 1 medication * CPAP should not be used for at least 2 weeks prior to first study PSG * History of using oral or nasal devices for the treatment of OSA may enroll as long as the devices are not used during participation in the study.