The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
The study population includes individuals affected by Alzheimer's Disease, mild cognitive impairment, other dementias, cognitively healthy individuals without memory problems, or their family members. Ascertainment is across both males and females, and all race and ethnic groups.
Study Type
OBSERVATIONAL
Enrollment
1,000
Blood draw for identification of genetic variants associated with the development of memory problems
Brief memory test
Collection of medical history
Columbia University Irving Medical Center
New York, New York, United States
RECRUITINGGenetic risk variants associated with early-onset dementia
Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers.
Time frame: 2 years
Changes in blood biomarkers in early-onset dementia
Blood biomarkers including plasma amyloid beta and tau protein will be assessed in blood and correlated with onset and progression of memory loss and functional impairment
Time frame: 2 years
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