Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

University of Southern Denmark22 enrolled

Overview

This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Type2 Diabetes

Interventions

Insulin clampDRUG

Continous infusion insulin + glucose

BQ123DRUG

Continuous infusion of Insulin + glucose + BQ123

BQ123 + BQ788DRUG

Continous infusion of insulin + glucose + BQ123 + BQ788

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Type 2 diabetes OR healthy control (no type 2 diabetes) * BMI\<32 Exclusion Criteria: * heart disease * pregnancy or birth within 3 month * smoking * Kidney disease * beta-blockers * insulin treatment (for type 2 diabetics)

Locations (1)

Cardiovascular and Renal Research

Odense, Denmark

Outcomes

Primary Outcomes

Glucose infusion rate

Glucose infusion rate required to maintain euglycemia during insulin clamp with and without endothelin blockade

Time frame: 3.5 hours

Leg blood flow

Effect of endothelin receptor blockade on leg blood flow (ultrasound Doppler) during insulin clamp with and without endothelin blockade

Time frame: 3.5 hours

Data from ClinicalTrials.gov

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