The aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patient undergoing a living donor kidney transplant under general anesthesia.
The purpose of this study was to investigate whether postoperative pain is significantly reduced when TQL block was additionally performed after surgery in patients undergoing living-donor kidney transplantation. Therefore, investigator hypothesized that the analgesic consumption for postoperative 24 hours will decrease in TQL group compared to the control group. For secondary outcomes, the pain score at rest/ movement up to 48 hours after surgery, the time until the first pain reliever is requested, whether and how often rescue analgesics are administered for 48 hours, the incidence and severity of nausea and vomiting during the 48 hours after surgery, patient's satisfaction with post-pain control and the number of hospital stays were investigated. Overall, the aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patients undergoing a living donor kidney transplantation under general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
88
Patients assigned to the TQL block group receive the TQL block in a supine position with the surgical site facing up before recovery of general anesthesia after surgery. For the block, 30cc of 0.375% ropivacaine is used.
For patients assigned to the control group, 30cc of 0.9% normal saline is used for TQL block.
Seoul National University Hospital
Seoul, South Korea
Analgesic consumption for 24 postoperative hours
Total analgesic use for 24 hours after surgery (morphine milligram equivalents (MME))
Time frame: 24 hours postoperatively
Analgesic consumption
Analgesic consumption at postoperative 6, 12, 48 hours
Time frame: at postoperative 6, 12, 48 hours
Resting pain numeric rating scale(NRS)
Resting pain numeric rating scale(NRS) at postoperative 6, 12, 24, 48 hours. Numeric rating scare is 11-point scale from 0 to 10, The higher the number, the more severe the pain (0 is no pain at all, 10 is the most severe pain imaginable).
Time frame: at postoperative 6, 12, 24, 48 hours
Numeric rating scale of pain during movement
Numeric rating scale of pain during movement at postoperative 6, 12, 24, 48 hours Numeric rating scare is 11-point scale from 0 to 10. The higher the number, the more severe the pain (0 is no pain at all, 10 is the most severe pain imaginable).
Time frame: at postoperative 6, 12, 24, 48 hours
Time to first rescue analgesics
Time to first rescue analgesics
Time frame: within post-operative 24 hours
Numeric rating scale at post anesthetic care unit (PACU)
Numeric rating scale at post anesthetic care unit Numeric rating scare is 11-point scale from 0 to 10. The higher the number, the more severe the pain (0 is no pain at all, 10 is the most severe pain imaginable).
Time frame: 30 minutes after the end of operation
Rescue analgesics administration
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Rescue analgesics administration count
Time frame: within post-operative 48 hours
The incidence of post-operative nausea and vomiting
The incidence of post-operative nausea and vomiting
Time frame: within post-operative 48 hours
Patient satisfaction with pain control
Patient satisfaction with pain control in 11 point scale (0-10), The higher the score, the higher the patient's satisfaction.
Time frame: At post-operative 48 hours
Pattern of injectate spread on ultrasonography
Pattern of injectate spread on ultrasonography
Time frame: During procedure quadratus lumborum (QL) block
Sensory blockade
After surgery, an alcohol swab is used to evaluate the loss of cold sensation. It is evaluated by dividing into nine regions bordering the rib margin on the side of the surgery, the horizontal line passing through the umbilicus and pubis, and the vertical line of the midclavicular line, anterior axillary line, and mid axillary line. If cold sensation is the same as the opposite part of the regions, marked as 2 points, if decreased marked as 1 point, and if not sensed at all, marked as 0 point.
Time frame: 30 minutes after the end of operation
Quality of Recovery Questionnaire (15-item Quality of Recovery)
Each item uses an 11-point numeric rating scale. The sum of the scores of the 15 items ranges from 0 to 150, with a high score indicating good quality of recovery.
Time frame: At post-operative 48 hours
The severity of post-operative nausea and vomiting
The severity of post-operative nausea and vomiting, The severity of the nausea and vomitting is asked to patient and expressed as none, mild, or severe.
Time frame: within post-operative 48 hours