Feasibility of Mobile Game System for Potential Treatment of Developmental Delays

Stanford University

Overview

The investigators will test the feasibility and preliminary efficacy of a Mobile game system meant to generate valuable data for measuring progress and building novel artificial intelligence models while delivering impactful education for and treatment of children with developmental delays such as autism. Investigators will enroll children with autism aged 2-8 years old and their neurotypical sibling or an unrelated neurotypical control (aged 2-8 years old).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Conditions

Autism Spectrum Disorder Autism

Interventions

Mobile Game System for Potential Treatment of Developmental DelaysOTHER

Mobile game system meant to generate valuable data for measuring progress and building novel artificial intelligence models while delivering impactful education for and treatment of children with developmental delays such as autism.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Parent or primary caregiver over 18 of a child with autism, we will enrich for children between the ages of 2 and 8 years old. 2. Autism diagnosis confirmed by a screener such as the Mobile Autism Risk Assessment (MARA) and or similar published tools. Exclusion Criteria: (1) Physical, intellectual, language related, or environmental limitations that prevent the ability for the family to play the game as intended.

Locations (1)

Stanford University

Stanford, California, United States

Outcomes

Primary Outcomes

Change in parent reported socialization subscale scores of the Vineland Adaptive Behavior Scales,2nd Edition (VABS-2) from baseline to week 12 Vineland Adaptive Behavior Scales, 2d edition (VABS-2) Socialization subscale of the Parent/Caregiver

The socialization subscale is up to 113 items, where raw scores are converted to Intelligence Quotient (IQ) type standard scores--v-scale scores (M=15, SD=3) where scores range from 1 to 24, and factor in age equivalents, growth scale values, and higher scores indicate better adaptive functioning.

Time frame: Baseline (Week 0), Week 12

Mobile Application Usage-Total games started.

App usage data by participants (children) comprised of total number of MojiMatch plus Charades Games started.

Time frame: Week 12

Secondary Outcomes

Change in parent reported social responsiveness from week 0 to week 12

The Social Responsiveness Scale-2 is a 65-item measure where parents rate their child selecting responses on a Likert Scale. This measure will be used to measure and identify social impairment associated with Autism Spectrum Disorder (ASD) and to quantify its severity Social Responsiveness Scale (SRS) raw scores measure social abilities with lower scores indicating better social skills. (Raw Score Range: 0 - 195 and T-Score Range: 37- above 90).

Time frame: Baseline (Week 0), Week 12

Change in mobile autism risk assessment score from week 0 to week 12

A level 2 screening tool that has been validated in several studies and that uses a brief parent questionnaire with a 2 minute home video to generate a classification score that indicates severity of the autism phenotype (ranging from no autistic symptoms to severe autism) as well as confidence in the classification.

Time frame: Baseline (Week 0), Week 12

Data from ClinicalTrials.gov

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