The aim of this study is to investigate the effect of parenteral L-Glutamine supplementation added to enteral nutrition on short-term ICU mortality (7 days) in Covid-19 diseased patients.
A written informed consent will be taken from the patients or their relatives. Patients with diagnosis of covid-19 with enteral nutrition will be enrolled. Patients will be randomly assigned to receive either standard enteral nutrition (Group EN) or intravenous glutamine supplementation to enteral nutrition (group GN) in a dose of glutamine of 0.4 g/kg/day during ICU stay.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Standard enteral nutrition according to ICU nutrition protocol for 7 days
Intravenous glutamine supplementation to enteral nutrition in a dose of dose of glutamine of 0.4 g/kg/day for 7days
Omar Soliman
Asyut, Assuit, Egypt
ICU mortality
Short-term ICU mortality for patients admitted in our ICU \& signed for study drugs, who will expire during the study
Time frame: 7 days
Neutrophil/lymphocyte ratio (NLR)
Assessing NLR at day zero \& day 7 to monitor inflammatory response
Time frame: 7 days
D- dimer level
Assessing D-dimer level at day zero \&day 7 to monitor coagulability status
Time frame: 7 days
ICU stay
Period of patients admission in ICU within duration of study
Time frame: 7 days
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