Vitamin D Supplementation on Outcome and Disease Activity.

Department of Medical Services Ministry of Public Health of Thailand60 enrolled

Overview

To study efficacy of Vitamin D on outcome and disease activity ; DAS28-ESR in Rheumatoid arthritis patients at Rajavithi hospital .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Rheumatoid Arthritis, Vitamin D , Disease Activity, DAS28ESR

Interventions

Vitamin D 2DRUG

Randomized allocation first arm : add on vitamin D supplementation 40,000 iu/week for 12 weeks

PlaceboDRUG

Second arm : add on placebo for 12 weeks

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 yrs old * RA diagnosed by ACR/EULAR 2010 * low to moderate disease activity * on stable NSAIDs and DMARDs for at least 1 month * Received Prednisolone less than or equal to 7.5 mg/day * serum calcium, phosphorus and ALP are within normal limit. Exclusion Criteria: * Chronic kidney disease stage 3 or higher * History of TB * History of Chronic liver disease * Pregnancy or breast-feeding * adjustment of immuno-suppressive drugs, steroid * other connective tissue disease * Vitamin D allergy * received other drugs which have vitamin D component * serum Vitamin D less than 10 ng/mL

Locations (1)

Rajavithi hospital

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

To study efficacy of vitamin D on disease activity RA patients at Rajavithi hospital

Determine disease activity by DAS28-ESR in relation with vitamin D supplementation.

Time frame: 12 weeks

To study efficacy of vitamin D on IL-6 in RA patients at Rajavithi hospital

DAS-28 ESR measure from swollen joint count, tender joint count, ESR and patient global assessment

Time frame: 12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.