Prediction of Lymph Node Invasion for Prostate Adenocarcinoma

University Hospital, Brest400 enrolled

Overview

Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Adenocarcinoma of the Prostate

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically proven adenocarcinoma of the prostate treated by prostatectomy with extensive lymph node dissection * Available pre-operative +/- PET choline Exclusion Criteria: * Unanalyzable pre-operative MRI

Locations (1)

CHRU Brest

Brest, France

RECRUITING

Outcomes

Primary Outcomes

Predicted risk of lymph-node involvement vs Briganti 2017

Comparison between the predicted risk of lymph node involvement based on the new algorithm and the predicted risk with the Briganti 2017