The liver is a key organ in metabolism and contributes to T2DM development and insulin resistance via unclear mechanisms that may involve liver fat accumulation, inflammatory signals, and immune cells are proposed to play an important role in the pathogenesis of both NAFLD and T2DM.
This study aims to define * The effects of PTX, Empagliflozin as an example of SGLT-2 inhibitors and UDCA on liver biomarkers and liver steatosis in type 2 diabetic patients. * Studying PTX, Empagliflozin as an example of SGLT-2 inhibitors and UDCA efficacy and safety as add-on therapy in type 2 diabetic patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
tablets to be taken orally once a day
tablets to be taken orally twice a day
tablets to be taken orally twice a day
Minya University Hospital
Minya, Egypt
liver fat content (percent)
measured by MRI-PDFF
Time frame: 6-months
fatty liver staging (0, I, II, and III)
using ultrasound
Time frame: 6-months
Changes in Serum Gamma glutamyl transferase (γ-GT)
IU/l
Time frame: 6-months
HbA1c (%)
Time frame: 6-months
Fasting and 2-hr post-prandial serum glucose (mg/dl)
Time frame: 6-months
Lipid profile
(serum triglycerides, total cholesterol, LDL, HDL) (mg/dl)
Time frame: 6-months
Changes in liver enzymes
AST (IU/l) and ALT (IU/l)
Time frame: 6-months
Changes in direct and total bilirubin
(mg/dl)
Time frame: 6-months
Changes in total protein and albumin
(g/l)
Time frame: 6-months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
just starch tablets without any active agents