There is no specific recommendation about antimicrobial treatment length for documented infections in chemotherapy induced febrile neutropenia. The aim of this study was to compare long versus short antibiotic course for bloodstream infection treatment in acute myeloid leukemia patients during febrile neutropenia. This monocentric retrospective comparative study included all consecutive bloodstream infection episodes among acute myeloid leukemia patients with febrile neutropenia for 3 years (2017-2019). Episodes were classified regarding the length of antibiotic treatment, considered as short course if the treatment lasted ≤7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was ≤10 days and ≤14 days, respectively. The primary outcome was the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
Study Type
OBSERVATIONAL
Enrollment
104
Antibiotic duration of treatment defined if the patient belonged to long course or short course group.
University Hospital
Poitiers, France
Bloodstream infection relapses
The primary outcome was to compare the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
Time frame: within 30 days of antibiotic discontinuation
Mortality
Comparison of mortality rate within 30 days of antibiotic discontinuation
Time frame: within 30 days of antibiotic discontinuation
Epidemiology of bacteria
Distribution of bacteria responsible for bloodstream infection
Time frame: at baseline
Risk factors for relapses
Analyse of risk factors for bloodstream infection relapses
Time frame: within 30 days of antibiotic discontinuation
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