Prediabetes, Exercise, and Appetite Regulation

University of Utah23 enrolled

Overview

The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.

The primary objective of this study is to understand the relationship between exercise modality and appetite regulation in a population with pre-diabetes. The study includes a screening visit to ensure eligibility of participants, baseline assessments, a resistance exercise intervention, and post intervention measurements. The variables of interest include, but are not limited to, hormonal responses to exercise training pertaining to appetite, food cravings, appetite ratings. activity levels, body composition, and ten repetition-max strength. The aim of this study is to better understand the mechanisms involved in the correlation or causation of any improvements in fitness and appetite regulation in a cohort with pre-diabetes.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

PreDiabetes Appetitive Behavior

Interventions

Resistance ExerciseBEHAVIORAL

Increasing strength and fitness and thereby influencing hormones and perceptions involved in appetite regulation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-50 years of age * BMI between 27-40 kg/m² * Hemoglobin A1c level between 5.7% and 6.4% * Physical Activity (less than 150 min/week moderate-intensity Physical Activity, no more than 1 session/week of resistance exercise) Exclusion Criteria: * Unstable Cardiovascular Disease * Uncontrolled hypertension * Severe hypertriglyceridemia * History of or active liver disease * Uncontrolled thyroid disease * Active cancer diagnosis * Smoking * Engaged in exercise or diet program * History of bariatric surgery * GI malabsorptive disorders * Significant diet intolerances * History of major psychiatric disorder * presence of alcohol or substance abuse; * medications affecting weight, * EI or EE in past 6 months; * women currently pregnant, lactating, less than 6 months post-partum, or postmenopausal.

Locations (1)

University of Utah

Salt Lake City, Utah, United States

Outcomes

Primary Outcomes

Changes in Appetite Rating

Hunger/Satiety before/after consumption of a meal

Time frame: Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal

Changes in Hormonal Response to Feeding

Assessment of Ghrelin levels analyzed in blood samples before/after feeding.

Time frame: Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal