HTX-011 in Spinal Surgery

Inclusion Criteria: * Is scheduled to undergo an open 1-3 level lumbar decompression surgery with or without fixation under general anesthesia. * Females are eligible only if not pregnant, not lactating, not planning to become pregnant during the study. Exclusion Criteria: * Has a contraindication of a known or suspected history of hypersensitivity or clinically significant idiosyncratic reaction to required study medications. * Has a history of severe allergic reaction due to aspirin or other NSAIDs, or known history of severe gastrointestinal adverse reactions associated with NSAID use. * Has functioning intrathecal drug pump or spinal cord stimulator. * Opioid use for most days within the last 3 months. * Has initiated treatment with selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (SNRIs), gabapentin, pregabalin, or duloxetine within 1 month prior to the scheduled surgery. * Received an investigational product or device in a clinical trial within 30 days or within 5 elimination half-lives. * Has a history of clinically significant cardiac abnormality, coronary artery bypass graft surgery within 12 months, or suspected coagulopathy or uncontrolled anticoagulation. * Has impaired balance and is at risk of falling. * Is currently undergoing treatment for hepatitis B, hepatitis C, or HIV. * Has undergone 3 or more surgeries within 12 months. * Has a known history of glucose-6-phosphate dehydrogenase deficiency. * Has History of liver cirrhosis, having an aspartate aminotransferase \>3 × the upper limit of normal (ULN), or having an alanine aminotransferase \>3 × ULN.