Cryoneurolysis for Cutaneous Neuropathic Pain

Inclusion Criteria: * Age \> 17 years * ASA (American Society of Anesthesiologists) physical status classification system I-III * Informed consent * Capable of subjective evaluation of pain * Capable of reading and understanding Danish and informed written consent * Average pain intensity \>49/100 on VAS in the primary focal pain area for a minimum of 6 months at the time of inclusion * Relevant injury (surgery or trauma) of peripheral nerves * Plausible cutaneous location of pain * In the area of pain, at least one of the following (1-8): (1) Hypo/anesthesia for touch/brush (2) Hypo/anesthesia for cold (3) Hypo/anesthesia for warmth (4) Hypo/anesthesia for pinprick (5) Allodynia for touch/brush (6) Allodynia for cold (7) Allodynia for warmth (8) Hyperalgesia for pinprick * Neuropathic pain score (Douleur Neuropathique en 4 Questions, DN-4) \>3/10 * Definitive diagnosis of neuropathic pain (Finnerup et al 2016) Exclusion Criteria: * Inability to cooperate * Inability to understand Danish * Allergy to local anesthetic * Infection in the area of cryo probe insertion * Significant competitive chronic pain * Progressive neurologic disease * Increased risk at needle insertion and cold exposure (e.g. Raynaud, coagulopathies) * Uncontrolled severe systemic disease * Implanted electronic devices unless approved by the relevant medical specialist * Previous cryoneurolysis with no relevant effect for the same neuropathic pain * Previous interventional pain therapy (e.g. spinal cord stimulation) with no relevant effect for the same neuropathic pain * Expected duration of life \< 2 years * Pregnancy * Abuse of alcohol, narcotics or medicine * Current psychiatric disease * Inclusion in other clinical trials * Ongoing patient complaint * Body mass index \< 18.5 or \> 34.9 kg/m2 * Change of pain therapy within the last 28 days prior to inclusion