single-center clinical trial studies have verified the safety and effectiveness of transcatheter arterial chemoembolization (TACE) combined with lenvatinib in preventing postoperative recurrence of microvascular invasion (MVI) positive HCC patients. Explore a new clinical first-line treatment plan for patients with liver cancer microvascular invasion after surgery.
Focusing on the current status of clinical treatment of microvascular invasion (MVI) positive postoperative hepatocellular carcinoma (HCC) , single-center clinical trial studies have verified the safety and effectiveness of transcatheter arterial chemoembolization (TACE) combined with lenvatinib in preventing postoperative recurrence of MVI-positive HCC patients. Explore a new clinical first-line treatment plan for patients with liver cancer microvascular invasion after surgery.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Lenvatinib is taken orally.
TACE treatment once.
Weilin Wang
Hangzhou, None Selected, China
RECRUITINGThe Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
RECRUITINGIncidence of adverse events
To evaluate the safety of TACE combined with lenvatinib treatment in preventing postoperative recurrence in patients with MVI-positive HCC
Time frame: Up to 8 weeks
Changes in tumor volume
To evaluate the effectiveness of TACE combined with lenvatinib treatment in preventing postoperative recurrence in patients with MVI-positive HCC
Time frame: Up to 8 weeks
Recurrence-free survival (RFS) evaluation
To evaluate the recurrence-free survival of patients with MVI-positive HCC after TACE combined with lenvatinib treatment
Time frame: Through study completion, an average of 1 year
Disease recurrence time evaluation
To evaluate the tumor recurrence time of patients with MVI-positive HCC after TACE combined with lenvatinib treatment
Time frame: Through study completion, an average of 1 year
Overall survival ( OS) evaluation
Overall survival time as assessed by IRC
Time frame: Through study completion, an average of 1 year
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