The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT). This study aimed to determine the association between preoperative ATIII level and postoperative acute kidney injury (AKI) after LT (post-LT AKI).
Study Type
OBSERVATIONAL
Enrollment
2,395
In liver transplant recipients with baseline antithrombin III levels lower than 50%, exogenous Antithrombin III was administrated during the anhepatic phase of the liver transplant surgery.
Asan Medical Center
Seoul, South Korea
acute kidney injury
serum creatinine \>0.3 mg/dL within POD 2 or increase by \>1.5 times within POD 7 according to the criteria set by the Kidney Disease: Improving Global Outcomes (KDIGO) classification
Time frame: postoperative 7 day
chronic kidney disease
glomerular filtration rate less than 60 mL∙min-1∙1.73m-2 on two consecutive occasions at least 3 months apart
Time frame: postoperative 3 months
early allograft dysfucion
at least one of the following: total bilirubin ≥10 mg/dL on postoperative day (POD) 7, prothrombin time (INR) ≥1.6 on POD 7, and alanine or aspartate aminotransferases \>2000 IU/L within POD 7
Time frame: postoperative 7 day
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