Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise

Hacettepe University111 enrolled

Overview

The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study. Healthy individuals of similar age, height and weight will also be included for references to normal serum cytokine levels. All patients will be evaluated twice, before and 6 weeks after treatment. The treatment program will be applied 3 times a week for 6 weeks under the supervision of a physiotherapist.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

111

Conditions

Low Back Pain

Interventions

Lumbal stabilization excercisesOTHER

The stabilization group will perform lumbal stabilization exercises in lying, sitting, standing and on a swisball 3 times a week during 6 weeks.

Conventional exercisesOTHER

The general exercise group will perform conventional exercises 3 times a week during 6 weeks.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for patients with disc herniation: * Diagnosis of disc herniation (protrusion, extrusion, sequestered disc) * not an indication for lumbar disc herniation surgery * for patients with neurological deficits, loss of strength, decrease in DTRs, loss of sensation and at least one positive SLR test and presence of radicular pain * pain intensity of VAS ≥ 3 * male and female patients between the ages of 20-55 Inclusion Criteria for heathy people * not having low back pain complaints in the past * female and male healthy individuals between the ages of 20-55 Exclusion Criteria: * systemic or inflammatory disease * pregnant or breastfeeding women * surgery of lumbar region * fracture of lumbar vertebrae * lumbar scoliosis * medication use for psychiatric disorders * tumor * allergy * neurological disease * alcohol-drug use * generalized musculoskeletal pain

Locations (1)

Faculty of Physiotherapy and rehabilitation

Ankara, Altındağ, Turkey (Türkiye)

Outcomes

Primary Outcomes

inflammatory cytokines

Tnf-alfa , IL-6, IL-4, IL-1β, Beta-endorphins, Anandamide, Arachidonoylgylycerol will be evaluated with ELISA kit.

Time frame: 6 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.