Prognosis Predicting of CRC Patients Based on Morphology and Molecular Biomaker of CTC

Fudan University1,000 enrolled

Overview

Detecting circulating tumor cells from I-IV stage colorectal cancer patients pre-and post-operatively. Analyzing the morphology and biomarkers of CTCs and builting prognosis predicting model based on the morphology and biomarkers of CTCs. Verifying the prognosis model by the survival data.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Colorectal Cancer Circulating Tumor Cell

Interventions

Circulating tumor cellDIAGNOSTIC_TEST

detecting circulating tumor cell pre- and post operatively

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-80 years; Histologically proven colorectal carcinoma (TNM stage I-IV) R0 resection is possible according to preoperative evaluation Written informed consent for participation in the trial. Exclusion Criteria: * Primary tumor or metastases not able to be removed radically Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy) Have other malignant tumors meanwhile Other previous malignancy within 5 years

Outcomes

Primary Outcomes

Sensitivity

The sensitivity of the predictive based on the number and type of circulating tumor cell

Time frame: 1 year

Specificity

The specificity of predictive model based on the number and type of circulating tumor cell

Time frame: 1 year

Secondary Outcomes

AUC

Area under curve of the predictive model

Time frame: 1 year

Central Contacts

Jianmin Xu

CONTACT

+8613501984869 xujmin@aiiyun.com

Data from ClinicalTrials.gov

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