This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.
The purpose of this research is to see if taking part in structured exercise training will improve the ability to exercise, the function of the lungs and the function of the heart, and reduce symptoms of fatigue and breathlessness in people recovering from COVID-19. After enrollment all patients will complete exercise testing, lung function testing, and cardiac imaging. Patients will be randomized to either 8 weeks of exercise training (4-5 times per week) or will continue standard medical care. All patients will undergo detailed exercise testing, lung function testing, and cardiac imaging after the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
27
8 week home-based exercise therapy 4-5 times/week
Mayo Clinic in Florida
Jacksonville, Florida, United States
Maximal oxygen update (VO2max) measured in mL/kg/min
VO2max is the maximal oxygen consumed during an exhaustive exercise test
Time frame: 8 weeks
Peak exercise work rate (Wpeak) measured in Watts
Wpeak is the highest achieved power during a maximal incremental cycle exercise test
Time frame: 8 weeks
Forced vital capacity (FVC) measured in L
FVC is the largest amount of air that can be exhaled from the lungs in one maximal breath
Time frame: 8 weeks
Forced expiratory volume in 1 second (FEV1) measured in L
FEV1 is the largest amount of air that can be exhaled from the lungs in the first second of one maximal breath
Time frame: 8 weeks
Maximal inspiratory pressure (MIP) measured in cmH2O
Highest inspiratory muscle pressure (i.e. inspiratory muscle strength) during a maximal inspiratory effort
Time frame: 8 weeks
Maximal expiratory pressure (MEP) measured in cmH2O
Highest expiratory muscle pressure (i.e. expiratory muscle strength) during a maximal expiratory effort
Time frame: 8 weeks
Left ventricular contractile function measured as % fractional area change (LV FAC)
LV FAC is a measure of overall contractile function of the LV
Time frame: 8 weeks
Right ventricular contractile function measured as % fractional area change (RV FAC)
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RV FAC is a measure of overall contractile function of the RV
Time frame: 8 weeks