Correlation of Intramedullary Pressure and Systemic Inflammatory Parameters in Cemented Femoral Stem

University Clinical Centre of Kosova60 enrolled

Overview

The cemented femoral stem have impact on increase on systemic parameters. Evaluation of the level of histamine, C-reactive protein (CRP) and leukocytes formula, IL1b, TNF alpha, IL6 and the reflection of changes of these parameters in the intra-operative course of hip replacement.

Implantation of total endoprosthesis is a very common surgical procedure and is performed with and without bone cement. In most cases during cementation of the femoral component there are changes in blood pressure, SpO2, heartbeat and other vital parameters which can cause complications during surgery. Comparing the system parameters between the two groups and deriving these results will help the medical staff to be more professionally prepared to resolve possible complications.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Arthroplasty Complications

Interventions

Hip ReplacementPROCEDURE

The hip replacement surgery is when a damaged hip is replaced with artificial one

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: The inclusion criteria were as follows: * All patients willing to participate who underwent cemented and uncemented THA, * With no limit on age Exclusion Criteria: The exclusion criteria were patients with: * Periprosthetic fractures, * Pathological fractures * THA revision * ASA IV

Locations (1)

University Clinical Center of Kosovo

Pristina, Kosovo

RECRUITING

Outcomes

Primary Outcomes

Change of systemic parameters during and after hip replacement (Histamine)

Analysis of the impact of cement in different laboratory parameters such as histamine

Time frame: The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications.

Change of systemic parameters during and after hip replacement (CRP)

Analysis of the impact of cement in different laboratory parameters such as C-reactive protein (CRP)

Change of systemic parameters during and after hip replacement (Leukocytes formula)

Analysis of the impact of cement in different laboratory parameters such as changes of leukocytes formula

Change of systemic parameters during and after hip replacement (IL1b)

Analysis of the impact of cement in different laboratory parameters such as IL1b

Change of systemic parameters during and after hip replacement (TNF alpha)

Analysis of the impact of cement in different laboratory parameters such are TNF alpha

Central Contacts

Skender Ukaj, MD

CONTACT

0038344603609 skender.ukaj@uni-gjk.org

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Secondary Outcomes

Difference of arterial pressure

Difference of arterial pressure after implantation of femoral component

Time frame: The changes will be measured 5 minutes before implantation and during first 10 minutes after implantation

Difference of changes of Leukocyte formula

Difference of changes of Leukocyte formula after implantation of femoral component

Time frame: The blood will be taken from patience 1 hour before and Post Operative Day One

Difference of SpO2

Difference of SpO2 after implantation of femoral component The changes will be measured by the device monitor connected to patient

Time frame: The changes will be measured 5 minutes before implantation and during first 10 minutes after implantation]