The REACH-B study establishes an observational cohort study of people living with chronic hepatitis B from a national network, including a diverse range of services, to characterise and monitor hepatitis B linkage to care and treatment requirements amongst this population.
Participants presenting to participating clinics for HBV care within the previous 12 months will be identified and enrolment data will be collected including demographics, laboratory parameters, liver disease assessment, treatment history and clinical management. Follow-up data on HBV treatment and clinical management, liver disease stage and laboratory parameters will be collected at each subsequent visit or at minimum every 12 months.
Study Type
OBSERVATIONAL
Enrollment
10,000
No intervention
Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM)
Sydney, New South Wales, Australia
Characterisation of HBV
To characterise and monitor hepatitis B linkage to care and treatment requirements amongst people living with chronic hepatitis B
Time frame: July 2027
Socio-demographics of HBV infected population
To characterise the socio-demographic spectrum of people living with chronic HBV
Time frame: July 2027
HBV Disease staging
To assess the proportion of individuals in each phase of the disease, based on the natural history of hepatitis B infection
Time frame: July 2027
HBV Care Cascade
To assess the proportion of individuals who are eligible for each recommended hepatitis B clinical care level
Time frame: July 2027
HBV Treatment and Care
To monitor the uptake of recommended hepatitis B clinical care, including antiviral treatment
Time frame: July 2027
HBV Care and treatment adherence
To monitor the adherence to recommended hepatitis B care, including the patterns of antiviral use and cessation
Time frame: July 2027
HCC Surveillance
To assess the rate of surveillance for hepatocellular carcinoma
Time frame: July 2027
HBV Disease Progression
To assess the rate of progression from each phase to the subsequent phase of hepatitis B
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St Vincent's Hospital
Sydney, New South Wales, Australia
RECRUITINGJustice Health and Forensic Mental Health Network
Sydney, New South Wales, Australia
RECRUITINGBlacktown Mount Druitt Hospital
Sydney, New South Wales, Australia
RECRUITINGWestmead Hospital
Sydney, New South Wales, Australia
RECRUITINGMenzies School of Health Research (Royal Darwin & Alice Springs Hospitals)
Darwin, Northern Territory, Australia
RECRUITINGTop End Medical Centre
Darwin, Northern Territory, Australia
RECRUITINGSunshine Coast University Hospital
Birtinya, Queensland, Australia
RECRUITINGCairns and Hinterland Hospital Health Service
Cairns, Queensland, Australia
RECRUITINGTorres and Cape Hospital and Health Service
Cairns, Queensland, Australia
RECRUITING...and 9 more locations
Time frame: July 2027
Liver fibrosis progression
To assess the rate of liver fibrosis progression, including the development of cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma
Time frame: July 2027