Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes

N/ARecruitingNCT04917471

Karolinska Institutet20 enrolled

Overview

To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

Type 2 Diabetes

Interventions

Beet root juiceDIETARY_SUPPLEMENT

70 ml bid

Placebo juiceDIETARY_SUPPLEMENT

70 ml bid

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Type 2 diabetes Exclusion Criteria: Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction \<35%) Any condition that interferes with the possibility to fulfill the study protocol

Locations (1)

Karolinska Institutet, Karolinska University Hospital

Stockholm, Sweden

RECRUITING

Outcomes

Primary Outcomes

Percentage recovery of left ventricular function

Red blood cells are administered to an isolated rodent heart subjected to 25 min global ischemia and 60 min reperfusion. The percentage recovery during reperfusion is determined.

Time frame: 1 week

Central Contacts

John Pernow

CONTACT

+46704848361 john.pernow@ki.se

Data from ClinicalTrials.gov

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